Across TCGA patient cohorts, LCE2A mutation is significantly associated with the RNA expression of many other genes, with 296 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCE2A-associated genes across cancer lineages are ADIRF, MIR6780A, and RNU1-75P. Each is linked with LCE2A in more than 1 cancer types. Because this analysis shows association rather than direction, both LCE2A-to-partner and partner-to-LCE2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCE2A→partner) and Y-score (partner→LCE2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ADIRF →	+0.055	+5.226	<.001	.003	3	2
COAD	MIR6780A →	+0.622	+5.080	.001	.008	3	2
LGG	RNU1-75P →	+0.449	+3.711	<.001	.008	3	1
LGG	SNORA1B →	+0.291	+4.351	<.001	.008	3	1
LGG	RNA5SP334 →	+0.204	+4.550	<.001	.006	3	1
LGG	CGB8 →	+0.058	+5.345	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 296 associations by consensus.

Exploration

LCE2A survival (RNA) · tumor vs normal (RNA) · all LCE2A data types