Across TCGA pan-cancer cohorts, LCE2A RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of LCE2A’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where LCE2A RNA is repressed in tumor relative to normal tissue. In most cancer types LCE2A is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

LUAD, COAD, and THCA are the cancer types where LCE2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LCE2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	−0.078	<.001	7	view →
COAD	All	All	−0.126	.001	5	view →
THCA	All	All	+0.012	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: LCE2A RNA expression & survival · all LCE2A data types