Across TCGA cell cohorts, LCE2A mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LCE2A-associated genes across cancer lineages are RXFP2, OR4E2, and RBMY1B. Each is linked with LCE2A in more than 1 cancer types. Because this analysis shows association rather than direction, both LCE2A-to-partner and partner-to-LCE2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCE2A→partner) and Y-score (partner→LCE2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RXFP2 →	+0.047	+4.684	<.001	.002	3	1
LARGE_INTESTINE	OR4E2 →	+0.009	+4.415	<.001	.007	3	1
LARGE_INTESTINE	RBMY1B →	+0.004	+4.415	<.001	.007	3	1
LARGE_INTESTINE	RBMY1D →	+0.004	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

LCE2A survival (RNA) · tumor vs normal (RNA) · all LCE2A data types