Across TCGA patient cohorts, LCE1A mutation is significantly associated with the RNA expression of many other genes, with 141 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCE1A-associated genes across cancer lineages are RNU6-971P, SPANXN2, and NDUFA5P8. Each is linked with LCE1A in more than 1 cancer types. Because this analysis shows association rather than direction, both LCE1A-to-partner and partner-to-LCE1A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCE1A→partner) and Y-score (partner→LCE1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-971P →	+0.291	+6.924	<.001	<.001	3	2
LUSC	SPANXN2 →	+0.133	+5.792	<.001	.003	3	2
CESC	NDUFA5P8 →	+0.182	+6.144	<.001	.001	3	1
CESC	MICG →	+0.314	+5.969	<.001	.002	3	1
CESC	RNU6-1299P →	+0.474	+5.201	<.001	.007	3	1
CESC	TYMSP2 →	+0.146	+5.103	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 141 associations by consensus.

Exploration

LCE1A survival (RNA) · tumor vs normal (RNA) · all LCE1A data types