LCA5L

Across TCGA patient cohorts, LCA5L mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCA5L-associated genes across cancer lineages are PCNA, PDCD4, and PKC-b-II_pS660. Each is linked with LCA5L in more than 2 cancer types. Because this analysis shows association rather than direction, both LCA5L-to-partner and partner-to-LCA5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by LCA5L-low versus LCA5L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCA5L→partner) and Y-score (partner→LCA5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.285	+2.070	<.001	.001	3	3
UCEC	PDCD4 →	-0.563	-2.312	<.001	.005	3	2
UCEC	PKC-b-II_pS660 →	-0.278	-1.736	.003	.007	3	2
UCEC	VHL →	-0.767	-1.678	.001	.021	3	2
UCEC	ASNS →	+0.348	+2.584	.005	.010	3	2
UCEC	CD49b →	-0.213	-2.095	.030	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PCNA by LCA5L expression — UCEC

Explore this box plot interactively →