LCA5L

Across TCGA cell cohorts, LCA5L mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LCA5L-associated genes across cancer lineages are CBLL2, TSPY8, and RBMY1A1. Each is linked with LCA5L in more than 1 cancer types. Because this analysis shows association rather than direction, both LCA5L-to-partner and partner-to-LCA5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBLL2 grouped by LCA5L-low versus LCA5L-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCA5L→partner) and Y-score (partner→LCA5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CBLL2 →	+0.036	+5.196	<.001	.005	3	1
OVARY	TSPY8 →	+0.045	+5.196	<.001	.005	3	1
OVARY	RBMY1A1 →	+0.143	+5.807	<.001	.001	3	1
LARGE_INTESTINE	TBC1D21 →	+0.020	+6.022	<.001	.001	3	1
LARGE_INTESTINE	CCER1 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	PYDC2 →	+0.145	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

CBLL2 by LCA5L expression — OVARY

Explore this box plot interactively →