LCA5L

Across TCGA cell cohorts, LCA5L mutation is significantly associated with the mutation status of many other genes, with 1,890 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LCA5L-associated genes across cancer lineages are SLC22A10, HHIP, and KLHL40. Each is linked with LCA5L in more than 3 cancer types. Because this analysis shows association rather than direction, both LCA5L-to-partner and partner-to-LCA5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC22A10 grouped by LCA5L-low versus LCA5L-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCA5L→partner) and Y-score (partner→LCA5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC22A10 →	+4.392	+4.392	.009	.009	1	4
OVARY	HHIP →	+3.977	+4.930	.001	.001	1	4
OVARY	KLHL40 →	+4.562	+5.217	<.001	<.001	1	3
OVARY	TNPO1 →	+4.977	+4.415	.007	.007	1	3
SKIN	PGM1 →	+4.392	+4.392	.009	.009	1	3
SKIN	TESMIN →	+4.392	+4.392	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,890 associations by consensus.

SLC22A10 by LCA5L expression — SKIN

Explore this box plot interactively →