LATS1

Across TCGA patient cohorts, LATS1 mutation is significantly associated with the RNA expression of many other genes, with 4,815 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LATS1-associated genes across cancer lineages are FAM136A, COX7A2, and LINC02497. Each is linked with LATS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LATS1-to-partner and partner-to-LATS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM136A grouped by LATS1-low versus LATS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LATS1→partner) and Y-score (partner→LATS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM136A →	+0.574	+2.110	<.001	<.001	3	4
UCEC	COX7A2 →	+0.396	+2.099	<.001	<.001	3	4
BRCA	LINC02497 →	+0.116	+5.009	.001	.002	3	3
UCEC	NOL12 →	+0.388	+1.890	<.001	<.001	3	3
UCEC	SENP3-EIF4A1 →	+0.107	+1.701	<.001	<.001	3	3
UCEC	CENPU →	+0.875	+3.534	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,815 associations by consensus.

FAM136A by LATS1 expression — UCEC

Explore this box plot interactively →