LATS1

Across TCGA pan-cancer cohorts, LATS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of LATS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LATS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LATS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KICH, and THCA are the cancer types where LATS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LATS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.773	<.001	11	view →
KICH	Female	All	−1.014	<.001	9	view →
THCA	All	All	−0.400	<.001	6	view →
CHOL	All	All	+1.457	<.001	4	view →
LIHC	All	All	+0.287	.010	4	view →
STAD	Male	II,III,IV	+0.730	.018	2	view →
UCEC	All	All	−0.600	.003	2	view →
ESCA	Female	All	+0.920	.015	1	view →
BRCA	Female	All	−0.187	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

LATS1–HNSC

Open the HNSC breakdown →