LAS1L

Across TCGA cell cohorts, LAS1L mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAS1L-associated genes across cancer lineages are VN1R4, SMYD1, and TKTL2. Each is linked with LAS1L in more than 1 cancer types. Because this analysis shows association rather than direction, both LAS1L-to-partner and partner-to-LAS1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R4 grouped by LAS1L-low versus LAS1L-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAS1L→partner) and Y-score (partner→LAS1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	VN1R4 →	+0.098	+5.754	<.001	.002	3	1
URINARY_TRACT	SMYD1 →	+0.020	+5.087	<.001	.004	3	1
LARGE_INTESTINE	TKTL2 →	+0.035	+3.187	.001	.006	3	1
LARGE_INTESTINE	NTSR2 →	+0.047	+2.793	.001	.002	3	1
LARGE_INTESTINE	SLC6A19 →	+1.594	+3.497	<.001	.004	3	1
LARGE_INTESTINE	NEXMIF →	+0.189	+3.196	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

VN1R4 by LAS1L expression — CNS

Explore this box plot interactively →