LAS1L

Across TCGA pan-cancer cohorts, LAS1L RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated LAS1L data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher LAS1L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LAS1L expression acts as an unfavorable survival marker, although some lineages such as KIRC and OV show a favorable association.

UVM, KIRC, and MESO are the cancer types where LAS1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.198	0.749	.003	58	view →
KIRC	DFS	Tertile	All	0.807	0.487	<.001	54	view →
MESO	DFS	Tertile	All	0.259	0.429	.005	40	view →
LIHC	OS	Tertile	All	0.588	0.777	<.001	33	view →
KICH	DFS	Tertile	All	0.812	1.000	.022	31	view →
OV	DFS	Quartile	II,III,IV	0.414	0.313	.012	30	view →
GBM	DFS	Quartile	All	0.506	0.233	.006	24	view →
LUSC	DFS	Tertile	III,IV	0.312	0.951	.003	23	view →
THYM	OS	Median	All	1.000	0.921	.010	19	view →
ACC	DFS	Median	III,IV	0.588	0.105	.003	19	view →
HNSC	DFS	Median	All	0.457	0.629	.016	19	view →
PAAD	OS	Median	All	0.532	0.742	.010	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

LAS1L–UVM (DFS)

Open the UVM breakdown →