LARP6

Across TCGA patient cohorts, LARP6 mutation is significantly associated with the RNA expression of many other genes, with 920 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LARP6-associated genes across cancer lineages are C1GALT1C1L, RN7SL248P, and RNU6-1137P. Each is linked with LARP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both LARP6-to-partner and partner-to-LARP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1GALT1C1L grouped by LARP6-low versus LARP6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARP6→partner) and Y-score (partner→LARP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	C1GALT1C1L →	-1.056	-2.800	.002	.003	3	3
UCEC	RN7SL248P →	+0.058	+3.059	<.001	.005	3	2
BRCA	RNU6-1137P →	+0.387	+5.646	<.001	.004	3	2
BRCA	RNU6-1290P →	+0.568	+5.610	<.001	.004	3	2
COAD	RPSAP35 →	+0.048	+5.153	<.001	.001	3	2
COAD	MRPL46 →	+0.429	+3.220	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 920 associations by consensus.

C1GALT1C1L by LARP6 expression — SKCM

Explore this box plot interactively →