LARP6

Across TCGA pan-cancer cohorts, LARP6 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LARP6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LARP6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LARP6 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and KICH are the cancer types where LARP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LARP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.033	<.001	10	view →
THCA	All	IV	−1.219	<.001	8	view →
KICH	Female	III,IV	−2.219	<.001	7	view →
BRCA	All	III,IV	−1.581	<.001	6	view →
LUSC	Male	All	+0.834	<.001	4	view →
CHOL	All	All	+2.274	<.001	3	view →
STAD	All	III,IV	−1.111	.017	2	view →
BLCA	Male	All	−0.871	.015	2	view →
UCEC	All	All	−0.702	.003	2	view →
LUAD	All	All	−0.375	.005	2	view →
PRAD	All	All	−0.220	.038	2	view →
KIRC	All	All	−0.181	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LARP6–HNSC

Open the HNSC breakdown →