LARP6

Across TCGA cell cohorts, LARP6 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible LARP6-associated genes across cancer lineages are FGF23, CYLC2, and SYNPR. Each is linked with LARP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both LARP6-to-partner and partner-to-LARP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF23 grouped by LARP6-low versus LARP6-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARP6→partner) and Y-score (partner→LARP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FGF23 →	+0.013	+4.510	.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	CYLC2 →	+0.012	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	SYNPR →	+0.019	+4.510	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	DEFB123 →	+0.085	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	OR52N5 →	+0.020	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	OR52E8 →	+0.102	+4.357	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

FGF23 by LARP6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →