Q-omics provides the consensus-scored LARGE-AS1 profile across patient tissues and cancer cell-line models. LARGE-AS1 expression is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, LARGE-AS1 is differentially expressed in 4, with the highest sampling consensus in HNSC. Additionally, LARGE-AS1 RNA expression shows 10,117 significant gene co-expression associations, with the highest sampling consensus in ESCA. Together, these results highlight KIRC, HNSC, and ESCA as cancer lineages where LARGE-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LARGE-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LARGE-AS1 survival associations across molecular data types. LARGE-AS1 RNA expression shows survival associations in the most cancer types (18). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LARGE-AS1 RNA expression–survival associations across cancer types. High LARGE-AS1 expression shows unfavorable associations in KIRC, ACC, LIHC and THYM, but favorable associations in BRCA and UVM. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for LARGE-AS1 RNA expression.
This table summarizes LARGE-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for LARGE-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LARGE-AS1 shows lower tumor expression in PAAD and LUAD and higher tumor expression in HNSC and BRCA. The HNSC box plot shows higher LARGE-AS1 RNA expression in tumor versus normal tissue (log2 FC = +0.018, t-test p = .035).
This table shows molecular features associated with LARGE-AS1 in patient tissues and cancer cell lines. In patient samples, LARGE-AS1 shows the broadest associations at the RNA and protein expression levels, with ESCA recurring as the lineage with the largest associated feature set.
