Across TCGA pan-cancer cohorts, LARGE-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LARGE-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LARGE-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LARGE-AS1 is over-expressed in tumor, although a few such as PAAD and LUAD show the opposite, repressed pattern.

HNSC, BRCA, and PAAD are the cancer types where LARGE-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LARGE-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.018	.035	3	view →
BRCA	All	All	+0.131	.028	2	view →
PAAD	Male	All	−0.035	.019	2	view →
LUAD	Female	II,III,IV	−0.050	.003	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: LARGE-AS1 RNA expression & survival · all LARGE-AS1 data types