LAPTM4B

Across TCGA patient cohorts, LAPTM4B mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAPTM4B-associated genes across cancer lineages are LINC02654, CCL1, and KLRC4. Each is linked with LAPTM4B in more than 1 cancer types. Because this analysis shows association rather than direction, both LAPTM4B-to-partner and partner-to-LAPTM4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02654 grouped by LAPTM4B-low versus LAPTM4B-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAPTM4B→partner) and Y-score (partner→LAPTM4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	LINC02654 →	+0.154	+5.733	<.001	.001	3	2
UCEC	CCL1 →	+0.243	+3.473	.003	<.001	3	1
UCEC	KLRC4 →	+0.303	+3.207	<.001	.002	3	1
UCEC	RN7SKP214 →	+0.456	+2.919	<.001	.002	3	1
UCEC	AWAT1 →	+0.648	+3.823	<.001	.002	3	1
UCEC	KRTAP20-3 →	+0.106	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

LINC02654 by LAPTM4B expression — LUSC

Explore this box plot interactively →