LAPTM4B

Across TCGA pan-cancer cohorts, LAPTM4B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated LAPTM4B data layer compared with 2 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher LAPTM4B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LAPTM4B expression acts as an unfavorable survival marker, although some lineages such as GBM and BLCA show a favorable association.

UVM, ACC, and LIHC are the cancer types where LAPTM4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.427	0.746	<.001	104	view →
ACC	DFS	Quartile	II,III,IV	0.294	0.817	<.001	98	view →
LIHC	OS	Median	All	0.365	0.588	<.001	95	view →
HNSC	OS	Quartile	All	0.607	0.789	<.001	61	view →
CESC	DFS	Quartile	All	0.603	0.812	.001	40	view →
KIRP	OS	Tertile	II,III,IV	0.140	0.790	.005	34	view →
SARC	OS	Median	All	0.414	0.607	<.001	33	view →
MESO	OS	Tertile	All	0.236	0.474	.004	30	view →
COAD	DFS	Median	II,III,IV	0.593	0.728	.003	17	view →
GBM	DFS	Median	All	0.388	0.191	.003	15	view →
SKCM	OS	Median	IV	0.221	0.780	.004	13	view →
STAD	DFS	Tertile	II,III,IV	0.369	0.665	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

LAPTM4B–UVM (DFS)

Open the UVM breakdown →