LAPTM4A

Across TCGA patient cohorts, LAPTM4A mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAPTM4A-associated genes across cancer lineages are RNU6-522P, RNU6-1122P, and RN7SL134P. Each is linked with LAPTM4A in more than 1 cancer types. Because this analysis shows association rather than direction, both LAPTM4A-to-partner and partner-to-LAPTM4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-522P grouped by LAPTM4A-low versus LAPTM4A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAPTM4A→partner) and Y-score (partner→LAPTM4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-522P →	+0.461	+5.411	<.001	.005	3	1
BLCA	RNU6-1122P →	+0.397	+6.289	<.001	.001	3	1
UCEC	RN7SL134P →	+0.150	+2.792	.001	.006	3	1
UCEC	MIR3915 →	+0.254	+4.566	<.001	.003	3	1
UCEC	MIR548AI →	+0.258	+4.566	<.001	.003	3	1
SKCM	IGLVIV-53 →	+0.094	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

RNU6-522P by LAPTM4A expression — BLCA

Explore this box plot interactively →