LAPTM4A

Across TCGA pan-cancer cohorts, LAPTM4A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated LAPTM4A data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LAPTM4A RNA is associated with better overall survival. In most high-consensus cancer types, elevated LAPTM4A expression acts as an unfavorable survival marker, although some lineages such as KIRC and THCA show a favorable association.

KIRC, HNSC, and UVM are the cancer types where LAPTM4A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Quartile	All	0.728	0.512	<.001	65	view →
HNSC	OS	Quartile	III,IV	0.352	0.553	.004	58	view →
UVM	DFS	Quartile	II,III,IV	0.233	0.805	<.001	49	view →
LGG	OS	Median	All	0.380	0.521	<.001	48	view →
PAAD	OS	Quartile	All	0.294	0.647	.001	37	view →
LIHC	DFS	Quartile	All	0.367	0.695	.002	37	view →
ACC	DFS	Quartile	All	0.288	0.795	<.001	26	view →
THCA	OS	Tertile	III,IV	1.000	0.892	.006	22	view →
LUSC	OS	Tertile	All	0.851	0.628	.010	18	view →
CESC	DFS	Quartile	All	0.366	0.686	.005	16	view →
BLCA	DFS	Quartile	III,IV	0.101	0.395	.014	15	view →
COAD	OS	Tertile	IV	0.801	0.250	.007	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

LAPTM4A–KIRC (OS)

Open the KIRC breakdown →