LAMTOR1

Across TCGA patient cohorts, LAMTOR1 mutation is significantly associated with the RNA expression of many other genes, with 736 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMTOR1-associated genes across cancer lineages are MIR7702, RNU6-340P, and MIR548F3. Each is linked with LAMTOR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAMTOR1-to-partner and partner-to-LAMTOR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7702 grouped by LAMTOR1-low versus LAMTOR1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMTOR1→partner) and Y-score (partner→LAMTOR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR7702 →	+0.481	+7.741	<.001	.009	3	2
COAD	RNU6-340P →	+0.363	+7.741	<.001	.009	3	1
COAD	MIR548F3 →	+0.361	+7.741	<.001	.009	3	1
COAD	H3P18 →	+0.093	+7.741	<.001	.009	3	1
COAD	IGHVII-1-1 →	+0.197	+7.741	<.001	.009	3	1
COAD	RN7SL673P →	+0.284	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 736 associations by consensus.

MIR7702 by LAMTOR1 expression — COAD

Explore this box plot interactively →