LAMP3

Across TCGA cell cohorts, LAMP3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAMP3-associated genes across cancer lineages are CEACAM4, COX6A2, and OR2C1. Each is linked with LAMP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAMP3-to-partner and partner-to-LAMP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEACAM4 grouped by LAMP3-low versus LAMP3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMP3→partner) and Y-score (partner→LAMP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CEACAM4 →	+0.022	+3.345	.001	.007	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR2C1 →	+0.092	+3.725	.006	.008	3	1
LARGE_INTESTINE	NXNL1 →	+0.119	+3.345	<.001	.007	3	1
LARGE_INTESTINE	OR10R2 →	+0.025	+3.977	<.001	.001	3	1
LARGE_INTESTINE	USP17L4 →	+0.017	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CEACAM4 by LAMP3 expression — LARGE_INTESTINE

Explore this box plot interactively →