LAMC1

Across TCGA cell cohorts, LAMC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,164 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LAMC1-associated GO terms across cancer lineages are Regulation of basement membrane organization, Hemidesmosome assembly, and Positive regulation of cell-substrate junction organization. Each is linked with LAMC1 in more than 14 cancer types. Because this analysis shows association rather than direction, both LAMC1-to-partner and partner-to-LAMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of basement membrane organization grouped by LAMC1-low versus LAMC1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMC1→partner) and Y-score (partner→LAMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Regulation of basement membrane organization →	+1.542	+3.002	<.001	<.001	3	15
BONE	Hemidesmosome assembly →	+0.418	+2.302	<.001	<.001	3	14
BONE	Positive regulation of cell-substrate junction organization →	+0.183	+2.214	<.001	<.001	3	13
BONE	Response to decreased oxygen levels →	+0.060	+1.651	<.001	<.001	3	13
BONE	Membrane protein proteolysis →	+0.134	+2.284	.004	.002	3	13
BONE	Biological process involved in interaction with host →	+0.087	+2.185	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,164 associations by consensus.

Regulation of basement membrane organization by LAMC1 expression — BLOOD_Myeloma

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