LAMC1

Across TCGA cell cohorts, LAMC1 mutation is significantly associated with the RNA expression of many other genes, with 1,206 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAMC1-associated genes across cancer lineages are LYZL2, C18orf63, and RAX2. Each is linked with LAMC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAMC1-to-partner and partner-to-LAMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYZL2 grouped by LAMC1-low versus LAMC1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMC1→partner) and Y-score (partner→LAMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LYZL2 →	+0.036	+5.977	<.001	.001	3	2
SOFT_TISSUE	C18orf63 →	+0.006	+5.369	<.001	.004	3	2
UPPER_AERODIGESTIVE_TRACT	RAX2 →	+0.023	+3.862	<.001	.002	3	2
LUNG_NSCLC_LUAD	FREM3 →	+0.087	+2.834	.001	.004	3	2
LUNG_NSCLC_LUAD	TEX43 →	+0.094	+3.040	<.001	.002	3	2
LUNG_NSCLC_LUAD	FRG2B →	+0.281	+3.529	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,206 associations by consensus.

LYZL2 by LAMC1 expression — SOFT_TISSUE

Explore this box plot interactively →