LAIR2

Across TCGA cell cohorts, LAIR2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. CNS shows the largest number of these associations.

The most reproducible LAIR2-associated genes across cancer lineages are NXF5, TCF23, and ZNF683. Each is linked with LAIR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAIR2-to-partner and partner-to-LAIR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXF5 grouped by LAIR2-low versus LAIR2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAIR2→partner) and Y-score (partner→LAIR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NXF5 →	+0.032	+4.087	<.001	.004	3	1
CNS	TCF23 →	+0.020	+3.643	<.001	.007	3	1
CNS	ZNF683 →	+0.027	+4.321	.007	.002	3	1
CNS	OR6C2 →	+0.076	+4.044	<.001	.003	3	1
CNS	SCN10A →	+0.137	+4.044	<.001	.003	3	1
CNS	AVPR1B →	+0.067	+4.449	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

NXF5 by LAIR2 expression — CNS

Explore this box plot interactively →