Across TCGA pan-cancer cohorts, LAGE3 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated LAGE3 data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LAGE3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated LAGE3 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

KIRC and SKCM are the cancer types where LAGE3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.146	0.808	.001	12	view →
SKCM	DFS	Median	All	1.000	0.198	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: LAGE3 tumor-vs-normal RNA expression · all LAGE3 data types