Across TCGA pan-cancer cohorts, LAGE3 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of LAGE3’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LAGE3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LAGE3 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
HNSC, COAD, and BLCA are the cancer types where LAGE3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LAGE3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.