Across TCGA patient cohorts, LAGE3 protein abundance is significantly associated with the RNA expression of many other genes, with 5,070 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible LAGE3-associated genes across cancer lineages are TTLL5, COQ6, and ANGEL1. Each is linked with LAGE3 in more than 4 cancer types. Because this analysis shows association rather than direction, both LAGE3-to-partner and partner-to-LAGE3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAGE3→partner) and Y-score (partner→LAGE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTLL5 →	+0.650	+0.467	<.001	<.001	3	5
BRCA	COQ6 →	+0.609	+0.342	<.001	<.001	3	5
BRCA	ANGEL1 →	+0.428	+0.282	.002	.008	3	4
UCEC	RPS6KA5 →	+0.583	+0.219	<.001	.006	3	4
BRCA	TMEM251 →	+0.600	+0.362	<.001	<.001	3	4
HNSC	SPATA7 →	+0.618	+0.194	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,070 associations by consensus.

Exploration

LAGE3 survival (RNA) · tumor vs normal (RNA) · all LAGE3 data types