Across TCGA patient cohorts, LAGE3 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAGE3-associated genes across cancer lineages are IGHV4-4, IL21, and AQP7P2. Each is linked with LAGE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAGE3-to-partner and partner-to-LAGE3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAGE3→partner) and Y-score (partner→LAGE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHV4-4 →	+2.531	+2.953	<.001	.007	3	1
UCEC	IL21 →	+0.276	+4.834	<.001	<.001	3	1
UCEC	AQP7P2 →	+0.261	+2.747	<.001	.009	3	1
UCEC	TEX43 →	+0.281	+2.851	.003	.009	3	1
UCEC	RNU4-82P →	+0.543	+4.086	.001	<.001	3	1
UCEC	RNA5SP358 →	+0.327	+3.198	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Exploration

LAGE3 survival (RNA) · tumor vs normal (RNA) · all LAGE3 data types