Across TCGA cell cohorts, LAGE3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAGE3-associated genes across cancer lineages are TKTL2, MSGN1, and PPP1R42. Each is linked with LAGE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAGE3-to-partner and partner-to-LAGE3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAGE3→partner) and Y-score (partner→LAGE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TKTL2 →	+0.056	+4.187	<.001	.002	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	PPP1R42 →	+0.098	+3.781	.001	.003	3	1
LARGE_INTESTINE	NEXMIF →	+0.279	+3.196	<.001	.007	3	1
LARGE_INTESTINE	TBX5 →	+0.251	+3.626	.001	.006	3	1
LARGE_INTESTINE	SLC5A5 →	+0.332	+3.453	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

LAGE3 survival (RNA) · tumor vs normal (RNA) · all LAGE3 data types