LAD1

Across TCGA patient cohorts, LAD1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,123 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible LAD1-associated genes across cancer lineages are GALNT3, TNNT2, and TNNI1. Each is linked with LAD1 in more than 6 cancer types. Because this analysis shows association rather than direction, both LAD1-to-partner and partner-to-LAD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LAD1 versus GALNT3 in BRCA, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAD1→partner) and Y-score (partner→LAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GALNT3 →	+1.262	+0.864	<.001	<.001	3	7
UCEC	TNNT2 →	+0.716	+0.659	.001	<.001	3	7
LUAD	TNNI1 →	+0.681	+0.846	<.001	<.001	3	7
LSCC	NECTIN4 →	+1.098	+0.626	<.001	<.001	3	6
LSCC	PTK6 →	+0.894	+0.493	<.001	<.001	3	5
UCEC	MALL →	+1.208	+0.657	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,123 associations by consensus.

LAD1 vs GALNT3 — BRCA

Explore this scatter interactively →