LACTB2

Across TCGA cell cohorts, LACTB2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LACTB2-associated genes across cancer lineages are NAA11, C10orf53, and C14orf180. Each is linked with LACTB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LACTB2-to-partner and partner-to-LACTB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAA11 grouped by LACTB2-low versus LACTB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LACTB2→partner) and Y-score (partner→LACTB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NAA11 →	+0.350	+3.443	.002	.009	3	1
LARGE_INTESTINE	C10orf53 →	+0.010	+3.217	.002	.006	3	1
LARGE_INTESTINE	C14orf180 →	+0.087	+3.155	.006	.008	3	1
LARGE_INTESTINE	ADAMTS4 →	+0.121	+3.333	<.001	.009	2	1
LARGE_INTESTINE	CFAP47 →	+0.181	+3.716	.009	.003	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

NAA11 by LACTB2 expression — LARGE_INTESTINE

Explore this box plot interactively →