KRTAP5-9

Across TCGA patient cohorts, KRTAP5-9 mutation is significantly associated with the RNA expression of many other genes, with 2,210 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP5-9-associated genes across cancer lineages are ITFG2-AS1, PGK1, and RPA3. Each is linked with KRTAP5-9 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP5-9-to-partner and partner-to-KRTAP5-9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITFG2-AS1 grouped by KRTAP5-9-low versus KRTAP5-9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP5-9→partner) and Y-score (partner→KRTAP5-9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ITFG2-AS1 →	+0.348	+2.053	.003	.005	3	2
UCEC	PGK1 →	+0.672	+2.847	.008	.001	3	2
UCEC	RPA3 →	+0.549	+3.180	.001	<.001	3	2
BRCA	MIR8056 →	+0.448	+7.471	<.001	.008	3	1
UCEC	IGHV1-69D →	+1.908	+3.180	<.001	<.001	3	1
UCEC	CCDC163 →	+0.451	+2.042	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,210 associations by consensus.

ITFG2-AS1 by KRTAP5-9 expression — UCEC

Explore this box plot interactively →