KRTAP5-9

Across TCGA patient cohorts, KRTAP5-9 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP5-9-associated genes across cancer lineages are PDCD4, 14-3-3_beta, and eEF2. Each is linked with KRTAP5-9 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP5-9-to-partner and partner-to-KRTAP5-9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by KRTAP5-9-low versus KRTAP5-9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP5-9→partner) and Y-score (partner→KRTAP5-9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.710	-3.459	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.096	-3.295	.020	.009	3	1
UCEC	eEF2 →	+0.396	+2.321	.007	.033	3	1
UCEC	eIF4E →	+0.173	+3.459	.046	.005	3	1
UCEC	A-Raf_pS299 →	-0.164	-2.584	<.001	.010	3	1
UCEC	ERK2 →	+0.163	+1.807	.040	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

PDCD4 by KRTAP5-9 expression — UCEC

Explore this box plot interactively →