KRTAP5-8

Across TCGA patient cohorts, KRTAP5-8 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP5-8-associated genes across cancer lineages are PCNA, FoxM1, and STAT3_pY705. Each is linked with KRTAP5-8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP5-8-to-partner and partner-to-KRTAP5-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by KRTAP5-8-low versus KRTAP5-8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP5-8→partner) and Y-score (partner→KRTAP5-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.288	+3.000	.021	.037	3	2
UCEC	FoxM1 →	+0.297	+3.000	.047	.037	2	2
UCEC	STAT3_pY705 →	-0.517	-3.000	<.001	.037	3	1
UCEC	p27_pT198 →	+0.130	+3.000	.035	.037	2	1
UCEC	Notch1 →	+0.172	+3.000	.034	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PCNA by KRTAP5-8 expression — UCEC

Explore this box plot interactively →