KRTAP5-8

Across TCGA cell cohorts, KRTAP5-8 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,317 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible KRTAP5-8-associated GO terms across cancer lineages are Negative regulation of transcription initiation by RNA polymerase II, Negative regulation of DNA-templated transcription initiation, and Post-transcriptional gene silencing. Each is linked with KRTAP5-8 in more than 8 cancer types. Because this analysis shows association rather than direction, both KRTAP5-8-to-partner and partner-to-KRTAP5-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of transcription initiation by RNA polymerase II grouped by KRTAP5-8-low versus KRTAP5-8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP5-8→partner) and Y-score (partner→KRTAP5-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of transcription initiation by RNA polymerase II →	+0.106	+0.095	<.001	.008	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of DNA-templated transcription initiation →	+0.106	+0.095	<.001	.008	3	9
OVARY	Post-transcriptional gene silencing →	+0.080	+0.129	<.001	.005	3	8
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.059	+0.090	<.001	.006	2	9
OVARY	Pre-mRNA catabolic process →	+0.122	+0.084	.001	.009	2	9
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to nucleus →	+0.060	+0.087	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,317 associations by consensus.

Negative regulation of transcription initiation by RNA polymerase II by KRTAP5-8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →