KRTAP5-8

Across TCGA cell cohorts, KRTAP5-8 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KRTAP5-8-associated genes across cancer lineages are REG1B, NKX2-6, and FAM24A. Each is linked with KRTAP5-8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP5-8-to-partner and partner-to-KRTAP5-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by KRTAP5-8-low versus KRTAP5-8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP5-8→partner) and Y-score (partner→KRTAP5-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	REG1B →	+0.142	+4.922	<.001	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	FAM24A →	+0.085	+5.969	<.001	.001	3	1
LARGE_INTESTINE	OR13C7 →	+0.026	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

REG1B by KRTAP5-8 expression — BLOOD_Leukemia

Explore this box plot interactively →