KRTAP5-7

Across TCGA patient cohorts, KRTAP5-7 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP5-7-associated genes across cancer lineages are MEK1, VHL, and Chk2_pT68. Each is linked with KRTAP5-7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP5-7-to-partner and partner-to-KRTAP5-7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by KRTAP5-7-low versus KRTAP5-7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP5-7→partner) and Y-score (partner→KRTAP5-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.437	+2.321	.017	.034	3	1
UCEC	VHL →	-0.728	-2.321	.032	.035	3	1
UCEC	Chk2_pT68 →	-0.206	-2.990	.027	.036	2	1
UCEC	Annexin-1 →	+0.762	+2.321	.003	.035	1	1
UCEC	Stathmin →	+0.170	+2.321	.013	.035	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MEK1 by KRTAP5-7 expression — UCEC

Explore this box plot interactively →