Across TCGA patient cohorts, KRTAP5-10 mutation is significantly associated with the RNA expression of many other genes, with 272 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible KRTAP5-10-associated genes across cancer lineages are IGKV2-23, RN7SKP47, and LACRT. Each is linked with KRTAP5-10 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP5-10-to-partner and partner-to-KRTAP5-10 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP5-10→partner) and Y-score (partner→KRTAP5-10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGKV2-23 →	+0.134	+4.722	<.001	.004	3	2
HNSC	RN7SKP47 →	+0.149	+5.655	<.001	.004	3	1
LUSC	LACRT →	+0.327	+5.211	<.001	.007	3	1
LUSC	RNU6-874P →	+0.411	+5.273	<.001	.006	3	1
LUSC	RNU6-425P →	+0.402	+6.309	<.001	.001	3	1
LUSC	RNU6-331P →	+0.335	+5.706	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 272 associations by consensus.

Exploration

KRTAP5-10 survival (RNA) · tumor vs normal (RNA) · all KRTAP5-10 data types