Across TCGA pan-cancer cohorts, KRTAP5-10 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated KRTAP5-10 data layer compared with 3 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher KRTAP5-10 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KRTAP5-10 expression acts as an unfavorable survival marker, although some lineages such as CESC and BLCA show a favorable association.

CESC, BLCA, and KIRC are the cancer types where KRTAP5-10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	III,IV	0.817	0.393	<.001	82	view →
BLCA	DFS	Tertile	All	0.570	0.443	.003	65	view →
KIRC	DFS	Tertile	All	0.690	0.886	.002	50	view →
BRCA	OS	Median	IV	0.783	0.359	.004	47	view →
OV	OS	Quartile	III,IV	0.749	0.867	.012	32	view →
ESCA	DFS	Tertile	II,III,IV	0.221	0.464	.003	29	view →
STAD	OS	Tertile	III,IV	0.787	0.314	.001	27	view →
SARC	DFS	Quartile	All	0.717	0.471	<.001	25	view →
UCS	OS	Tertile	IV	0.206	0.844	.024	24	view →
THYM	DFS	Quartile	All	1.000	0.665	.002	23	view →
MESO	DFS	Quartile	III,IV	0.907	0.260	.017	18	view →
SKCM	OS	Median	All	0.866	0.716	.009	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

Exploration

Same gene, other analysis: KRTAP5-10 tumor-vs-normal RNA expression · all KRTAP5-10 data types