KRTAP4-7

Across TCGA patient cohorts, KRTAP4-7 mutation is significantly associated with the RNA expression of many other genes, with 230 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP4-7-associated genes across cancer lineages are PIN1P1, FTH1P21, and FTH1P13. Each is linked with KRTAP4-7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP4-7-to-partner and partner-to-KRTAP4-7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIN1P1 grouped by KRTAP4-7-low versus KRTAP4-7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP4-7→partner) and Y-score (partner→KRTAP4-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIN1P1 →	+0.116	+3.054	.003	.001	3	2
UCEC	FTH1P21 →	+0.399	+3.850	<.001	.002	3	2
UCEC	FTH1P13 →	+0.526	+3.844	<.001	<.001	3	2
UCEC	RN7SL147P →	+0.186	+2.550	.003	.006	3	2
UCEC	MIR7702 →	+0.338	+4.890	<.001	.002	3	2
COAD	RPL32P17 →	+0.626	+3.463	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 230 associations by consensus.

PIN1P1 by KRTAP4-7 expression — UCEC

Explore this box plot interactively →