KRTAP4-7

Across TCGA pan-cancer cohorts, KRTAP4-7 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated KRTAP4-7 data layer compared with 6 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher KRTAP4-7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRTAP4-7 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LUAD show a favorable association.

SKCM, LIHC, and LAML are the cancer types where KRTAP4-7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	All	0.323	0.628	<.001	96	view →
LIHC	OS	Tertile	All	0.145	0.786	<.001	63	view →
LAML	DFS	Tertile	All	0.135	0.590	<.001	54	view →
READ	DFS	Tertile	II,III,IV	0.569	0.811	.018	24	view →
KIRP	OS	Tertile	All	0.311	0.729	.009	24	view →
BRCA	DFS	Tertile	IV	0.665	0.224	.027	18	view →
KIRC	DFS	Tertile	IV	0.114	0.640	.002	18	view →
LUSC	DFS	Tertile	III,IV	0.182	0.558	.030	18	view →
PCPG	DFS	Tertile	All	0.080	0.767	<.001	18	view →
KICH	DFS	Tertile	All	0.162	0.862	.014	15	view →
LUAD	OS	Tertile	II,III,IV	0.780	0.219	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

KRTAP4-7–SKCM (DFS)

Open the SKCM breakdown →