KRTAP4-6

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, KRTAP4-6 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP4-6-associated genes across cancer lineages are Tuberin, Collagen-VI, and eIF4E. Each is linked with KRTAP4-6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP4-6-to-partner and partner-to-KRTAP4-6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP4-6→partner) and Y-score (partner→KRTAP4-6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECTuberin →+0.499+2.817.001.03631
UCECCollagen-VI →-0.254-3.000.033.03731
UCECeIF4E →+0.248+3.000.042.03721
UCECSTAT3_pY705 →-0.570-3.000<.001.03721
UCECCDK1_pY15 →+0.306+2.829.016.03621
UCECCyclin-B1 →+0.894+3.000.005.03721
Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

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