KRTAP4-4

Across TCGA cell cohorts, KRTAP4-4 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible KRTAP4-4-associated genes across cancer lineages are CD300H, CEACAM3, and KRTAP2-4. Each is linked with KRTAP4-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP4-4-to-partner and partner-to-KRTAP4-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD300H grouped by KRTAP4-4-low versus KRTAP4-4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP4-4→partner) and Y-score (partner→KRTAP4-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CD300H →	+0.052	+5.415	<.001	.004	3	2
BLOOD_Myeloma	CEACAM3 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KRTAP2-4 →	+0.049	+4.807	<.001	.006	3	1
BLOOD_Myeloma	PIGY →	+0.846	+4.807	.001	.006	3	1
LARGE_INTESTINE	DRD3 →	+0.012	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CD300H by KRTAP4-4 expression — LARGE_INTESTINE

Explore this box plot interactively →