KRTAP4-4

Across TCGA pan-cancer cohorts, KRTAP4-4 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated KRTAP4-4 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher KRTAP4-4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRTAP4-4 expression acts as an unfavorable survival marker, although some lineages such as ESCA and UCS show a favorable association.

KICH, BLCA, and ESCA are the cancer types where KRTAP4-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.081	0.904	<.001	90	view →
BLCA	OS	Tertile	IV	0.184	0.599	<.001	90	view →
ESCA	OS	Tertile	All	0.885	0.630	.004	78	view →
MESO	OS	Tertile	All	0.130	0.557	.019	54	view →
SKCM	DFS	Tertile	IV	0.036	0.433	<.001	45	view →
CESC	OS	Tertile	IV	0.149	0.614	.002	36	view →
OV	OS	Tertile	IV	0.028	0.759	.002	36	view →
HNSC	OS	Tertile	II,III,IV	0.180	0.605	.004	27	view →
STAD	DFS	Tertile	III,IV	0.296	0.646	.002	24	view →
UCEC	DFS	Tertile	All	0.723	0.850	.003	24	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	18	view →
PRAD	OS	Tertile	All	0.887	0.992	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

KRTAP4-4–KICH (DFS)

Open the KICH breakdown →