KRTAP4-2

Across TCGA patient cohorts, KRTAP4-2 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible KRTAP4-2-associated genes across cancer lineages are DNAJB8, C17orf102, and SNORD113-4. Each is linked with KRTAP4-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP4-2-to-partner and partner-to-KRTAP4-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAJB8 grouped by KRTAP4-2-low versus KRTAP4-2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP4-2→partner) and Y-score (partner→KRTAP4-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DNAJB8 →	+0.010	+2.931	<.001	.006	3	1
SKCM	C17orf102 →	+0.040	+2.587	<.001	.009	3	1
SKCM	SNORD113-4 →	+0.551	+3.224	<.001	.007	3	1
SKCM	GYG2P1 →	+0.738	+3.741	.009	.002	3	1
SKCM	MIR656 →	+0.495	+4.199	<.001	.001	3	1
SKCM	RPS4XP4 →	+0.078	+2.793	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

DNAJB8 by KRTAP4-2 expression — SKCM

Explore this box plot interactively →