KRTAP4-2

Across TCGA pan-cancer cohorts, KRTAP4-2 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated KRTAP4-2 data layer compared with 5 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher KRTAP4-2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRTAP4-2 expression acts as an unfavorable survival marker, although some lineages such as UCS and ESCA show a favorable association.

SKCM, MESO, and BLCA are the cancer types where KRTAP4-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	All	0.297	0.628	<.001	138	view →
MESO	OS	Tertile	III,IV	0.052	0.567	<.001	108	view →
BLCA	DFS	Tertile	All	0.385	0.641	<.001	99	view →
UCS	DFS	Tertile	II,III,IV	1.000	0.358	.007	60	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	54	view →
OV	DFS	Tertile	All	0.329	0.547	.002	54	view →
KIRC	DFS	Tertile	IV	0.090	0.641	<.001	48	view →
ACC	OS	Tertile	All	0.158	0.623	.012	36	view →
CHOL	OS	Tertile	All	0.154	0.793	.004	27	view →
ESCA	OS	Tertile	III,IV	0.792	0.348	.019	24	view →
LIHC	OS	Tertile	II,III,IV	0.289	0.778	.001	18	view →
PRAD	OS	Tertile	All	0.770	0.990	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

KRTAP4-2–SKCM (DFS)

Open the SKCM breakdown →