KRTAP4-16

Across TCGA cell cohorts, KRTAP4-16 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRTAP4-16-associated genes across cancer lineages are CLDN8, CYP11B2, and FAM205C. Each is linked with KRTAP4-16 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP4-16-to-partner and partner-to-KRTAP4-16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN8 grouped by KRTAP4-16-low versus KRTAP4-16-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP4-16→partner) and Y-score (partner→KRTAP4-16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CLDN8 →	+0.015	+4.930	<.001	.008	3	1
SOFT_TISSUE	CYP11B2 →	+0.013	+4.930	<.001	.008	3	1
SOFT_TISSUE	FAM205C →	+0.063	+4.930	<.001	.008	3	1
LARGE_INTESTINE	CRP →	+0.067	+4.415	<.001	.007	3	1
LARGE_INTESTINE	SCGB3A2 →	+0.352	+4.095	.002	.009	3	1
LARGE_INTESTINE	VCX2 →	+1.507	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

CLDN8 by KRTAP4-16 expression — SOFT_TISSUE

Explore this box plot interactively →