KRTAP25-1

Across TCGA patient cohorts, KRTAP25-1 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP25-1-associated genes across cancer lineages are RNU1-17P, RNU4-58P, and RNU6-206P. Each is linked with KRTAP25-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP25-1-to-partner and partner-to-KRTAP25-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-17P grouped by KRTAP25-1-low versus KRTAP25-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP25-1→partner) and Y-score (partner→KRTAP25-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU1-17P →	+0.463	+3.935	<.001	.003	3	1
UCEC	RNU4-58P →	+0.441	+4.133	<.001	.002	3	1
UCEC	RNU6-206P →	+0.372	+5.245	<.001	.002	3	1
UCEC	CDC14C →	+0.110	+4.134	<.001	.001	3	1
UCEC	SEPTIN7P8 →	+0.264	+3.903	<.001	.004	3	1
UCEC	SNORD121A →	+0.654	+3.258	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

RNU1-17P by KRTAP25-1 expression — UCEC

Explore this box plot interactively →