KRTAP11-1

Across TCGA patient cohorts, KRTAP11-1 mutation is significantly associated with the RNA expression of many other genes, with 967 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible KRTAP11-1-associated genes across cancer lineages are FOXRED2, PPM1G, and AGGF1P6. Each is linked with KRTAP11-1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRTAP11-1-to-partner and partner-to-KRTAP11-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXRED2 grouped by KRTAP11-1-low versus KRTAP11-1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP11-1→partner) and Y-score (partner→KRTAP11-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FOXRED2 →	+0.653	+2.596	.001	.005	3	3
LUAD	PPM1G →	+0.371	+2.099	.001	.003	3	3
CESC	AGGF1P6 →	+0.068	+6.569	<.001	.001	3	2
LUAD	SMC1B →	+1.152	+3.259	<.001	<.001	3	2
LUAD	SF3B2 →	+0.389	+3.782	<.001	<.001	3	2
LUAD	METTL2A →	+0.382	+3.771	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 967 associations by consensus.

FOXRED2 by KRTAP11-1 expression — LUAD

Explore this box plot interactively →